Mechanical injury of the endometrium
This procedure is relatively easy. Litterally, a minor superficial injury of the endometrium is performed by means of a thin plastic catheter; the goal is to enhance embryo implantation rates.
The endometrial injury causes a regeneration reaction, which may increase embryo implantation rates. Two mechanisms are thought to be activated:
The regeneration process releases growth factors, hormones and other molecules. New endometrial tissue growing after the procedure may be more receptive to embryos, thereby increasing the chances of pregnancy.
'Gene activation' - scientists believe that the genes responsible for embryo implantation are sometimes 'disabled'. Endometrial scratching is thought to activate these genes, thereby increasing the chance of pregnancy.
The best time to perform this procedure is around the 21st day of the cycle. The procedure is not painful and requires no prior preparation, since sedation is not required.